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Physical Sciences → Chemistry → Organic Chemistry

Synthesis and biological activity

This cluster of papers focuses on the synthesis, biological activities, and therapeutic potential of heterocyclic compounds, particularly in the context of drug discovery. The research covers a wide range of applications, including the development of anticancer agents, tubulin inhibitors, vascular targeting agents, and anti-inflammatory/antioxidant compounds.

98.9K works worldwide922.4K citations
Heterocyclic CompoundsMedicinal ChemistryAnticancer AgentsTubulin InhibitorsVascular Targeting AgentsChalconesCoumarinsPyrazolesThiazolesBenzimidazoles

Journals publishing in this area

1International Journal of Advanced Chemistry Research cover
International Journal of Advanced Chemistry Research
ISSN 2664-678117 articles in this topic
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Articles on Scinovex in this research area

47 articles, most cited first

  1. Synthesis and anti-tubercular activity evaluation of hydrazide-hydrazone derivatives
    International Journal of Advanced Chemistry Research · 2025 · 1 citations · AI summary
  2. In silico characterization, homology modelling and structure-based functional annotation of Labeo rohita TLR4 protein
    International Journal of Advanced Biochemistry Research · 2024 · 1 citations · AI summary
  3. Microwave assisted organic synthesis of nitrogen, oxygen and sulphur containing heterocycles
    International Journal of Advanced Chemistry Research · 2023 · 1 citations · AI summary
  4. Comprehensive Review on: Chemistry and Biological Potential of 2- Azetidinone
    International Journal of Advanced Chemistry Research · 2026 · 0 citations · AI summary
  5. Synthesis, docking studies, and in vitro antimicrobial and anticancer assessment of Mannich derivatives
    International Journal of Advanced Chemistry Research · 2026 · 0 citations · AI summary
  6. Preparation and characterization of triamterene complex with Diethyl 1-chlorohydrazine-1, 2-dicarboxylate
    International Journal of Advanced Chemistry Research · 2026 · 0 citations · AI summary
  7. QSAR-based evaluation of novel heterocyclic compounds as potential anticancer agents
    International Journal of Advanced Chemistry Research · 2026 · 0 citations · AI summary
  8. Design, synthesis, molecular docking, and ADMET evaluation of heterocyclic compounds as anticancer and antibacterial agents
    International Journal of Advanced Chemistry Research · 2026 · 0 citations · AI summary
  9. Pyrrolidine-mediated prodrug strategy for ibuprofen: Synthesis, characterization and biological evaluation
    International Journal of Advanced Chemistry Research · 2026 · 0 citations · AI summary
  10. Schiff base metal complexes as potential anticancer agents: Biological evaluation, and in silico studies
    International Journal of Advanced Chemistry Research · 2026 · 0 citations · AI summary
  11. Apoptosis and ROS assessment of a 2-thioxoimidazolidin-4-one analogue using HepG2 cells
    International Journal of Advanced Biochemistry Research · 2025 · 0 citations
  12. Design and synthesis of novel chalcone-aminoalkyl hybrids and evaluation of their antibacterial activity
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  13. Discovery of chromen-2-one based hybrid molecules as potential anti-tubercular agents and their docking for MTB
    International Journal of Advanced Chemistry Research · 2025 · 0 citations
  14. Rational design of chalcone and pyrazole analogues inspired by curcumin: Synthesis and biological assessment
    International Journal of Advanced Chemistry Research · 2025 · 0 citations
  15. Design, synthesis and antimicrobial activity of amide derivatives of pyrimidine-piperidine hybrids
    International Journal of Advanced Chemistry Research · 2025 · 0 citations
  16. Synthesis and docking-based evaluation of mannich derivatives targeting estrogen receptors in mcf-7 cells and evaluation of antibacterial activity
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  17. Cytotoxic activity and Molecular docking studies of chalcone linked Isatin derivatives
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  18. Bridging molecular design and global health equity: A critical review of quinolone-heterocycle hybrids as next-generation antimicrobials
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  19. Microwave-assisted synthesis and characterization of bioactive Benzimidazole-Oxadiazole Hybrids
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  20. Applicability of Deep Eutectic Solvent as a Sustainable Reaction Medium in Biocatalytic Multicomponent Synthesis
    International Journal of Advanced Chemistry Research · 2025 · 0 citations
  21. Synthesis and structure-activity relationships of isoxazole-based anti-inflammatory agents
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  22. Synthesis of benzothiophene sulfonamide derivatives as carbonic anhydrase inhibitors
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  23. Mechanochemical grinding synthesis of chalcone derivatives without solvent
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  24. Solvent-free synthesis of pyrazoline derivatives using grinding technique
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  25. Molecular docking and ADMET prediction of novel thiazolidinedione derivatives as PPAR-γ agonists
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  26. Synthesis and evaluation of curcumin analogues as dual COX-2/5-LOX inhibitors
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  27. Synthesis and anticonvulsant activity of novel 1,3,4-oxadiazole derivatives
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  28. In silico ADMET prediction and pharmacokinetic profiling of benzoxazole anticancer candidates
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  29. Bioisosteric replacement strategy in the development of novel analgesic compounds
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  30. Novel azo dyes derived from 4-aminoantipyrine: Synthesis, spectral and biological evaluation
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  31. Microwave-assisted one-pot synthesis of benzimidazole derivatives with enhanced bioactivity
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  32. Synthesis and anticonvulsant activity of novel 1,3,4-oxadiazole derivatives
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  33. Copper-catalysed synthesis of 2-substituted benzimidazoles under microwave conditions
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  34. Synthesis and biological evaluation of transition metal complexes of thiosemicarbazone schiff bases
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  35. Ultrasound-assisted synthesis and antioxidant evaluation of novel thiazole derivatives
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  36. Synthesis of chromene derivatives via knoevenagel condensation and their anticancer screening
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  37. Design, synthesis and molecular docking research of novel thiazolidinedione antidiabetic agents
    International Journal of Advanced Chemistry Research · 2025 · 0 citations · AI summary
  38. Synthesis, antibacterial and in silico study of 1, 3, 4 oxadiazole, triazole compounds derived from paracetamol
    International Journal of Advanced Chemistry Research · 2024 · 0 citations · AI summary
  39. Design and synthesis of some novel 1, 3, 5-trisubstituted pyrazolines derivatives for antimicrobial activities
    International Journal of Advanced Chemistry Research · 2024 · 0 citations · AI summary
  40. Synthesis of some novel benzimidazole derivatives act as antibreast cancer activity
    International Journal of Advanced Chemistry Research · 2024 · 0 citations · AI summary
  41. Biochemical evaluation of novel antibacterial compounds
    International Journal of Advanced Biochemistry Research · 2024 · 0 citations
  42. Molecular docking and ADMET profiling of flavonoid derivatives as potential inhibitors of cyclooxygenase-2 enzyme
    International Journal of Advanced Chemistry Research · 2024 · 0 citations · AI summary
  43. Synthesis and characterization of some new Sulfamethoxazole derivatives
    International Journal of Advanced Chemistry Research · 2023 · 0 citations · AI summary
  44. Cytotoxic activity, corrosion inhibition activity and molecular docking studies of Imidazolone scaffolds-A review
    International Journal of Advanced Chemistry Research · 2021 · 0 citations · AI summary
  45. Synthesis of 6-aryl-7-arylazo-4-(N-substituted aminomethyl)-2H-thiazolo-[3, 2-a]-1, 3, 5-triazino-2-thiones as Antiviral Agents
    International Journal of Advanced Biochemistry Research · 2020 · 0 citations · AI summary
  46. A mini review diverse biological activities of heterocyclic indole analogues
    International Journal of Advanced Chemistry Research · 2019 · 0 citations
  47. A Kinetic approach to oxidation of p methoxy-benzaldehyde di-nbutyl acetal by n-chloroisonicotinamide in aqueous acetonitrile acid medium: A comprehensive and mechanistic study
    International Journal of Advanced Chemistry Research · 2019 · 0 citations · AI summary