article Open AccessTop 1% cited
SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
Cell Metabolism · 2008 · Vol. 8(3) · pp. 224–236
Thomas Porstmann✉(The Honourable Society of Lincoln's Inn)Cláudio R. Santos(The Honourable Society of Lincoln's Inn)B Griffiths(The Honourable Society of Lincoln's Inn)Megan Cully(The Honourable Society of Lincoln's Inn)Mary Wu(The Honourable Society of Lincoln's Inn)Sally J. Leevers(Cancer Research UK)John R. Griffiths(Cancer Research UK)Yuen‐Li Chung(Cancer Research UK)Almut Schulze(The Honourable Society of Lincoln's Inn)
PI3K/AKT/mTOR signaling in cancerCholesterol and Lipid MetabolismUbiquitin and proteasome pathwaysmTORC1Cell biologyProtein kinase BPI3K/AKT/mTOR pathwayCell growthCancer researchBiologySignal transductionBiochemistry
MeSH terms
AnimalsCell NucleusCells, CulturedDrosophilaLipidsTranscription FactorsSignal TransductionGene ExpressionSirolimusDrosophila ProteinsRNA InterferenceCell EnlargementProto-Oncogene Proteins c-aktSterol Regulatory Element Binding Protein 1
Funding
- Cancer Research UK
Citations
1,365
FWCI
18.34
field-weighted impact
References
58
Percentile
100%
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Cell · 2007 · 6,033 citations
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
Developmental Cell · 2006 · 1,398 citations
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Nature Cell Biology · 2002 · 3,038 citations
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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Nature Cell Biology · 2007 · 1,164 citations
TOR Signaling in Growth and Metabolism
Cell · 2006 · 5,743 citations
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