review Open AccessTop 1% cited
AKT/PKB Signaling: Navigating Downstream
Cell · 2007 · Vol. 129(7) · pp. 1261–1274
Brendan D. Manning✉(Harvard University)Lewis C. Cantley(Beth Israel Deaconess Medical Center)
PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancerFOXO transcription factor regulationProtein kinase BBiologyProto-Oncogene Proteins c-aktCell biologyAKT1Signal transductionPI3K/AKT/mTOR pathwayAngiogenesisAKT2Kinase
MeSH terms
Cell MovementCell SurvivalEnergy MetabolismPhosphorylationSubstrate SpecificitySignal TransductionNeovascularization, PhysiologicCell EnlargementCell ProliferationProto-Oncogene Proteins c-akt
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References
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Developmental Cell · 2006 · 1,398 citations
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Nature Reviews Genetics · 2006 · 3,288 citations
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
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