article Open AccessTop 1% cited
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
Developmental Cell · 2006 · Vol. 11(6) · pp. 859–871
David A. Guertin✉(Broad Institute)Deanna M. Stevens(Whitehead Institute for Biomedical Research)Carson C. Thoreen(Whitehead Institute for Biomedical Research)Aurora A. Burds(Center for Cancer Research)Nada Y. Kalaany(Whitehead Institute for Biomedical Research)Jason Moffat(Broad Institute)Michael Brown(Center for Cancer Research)Kevin Fitzgerald(Bristol-Myers Squibb (United States))David M. Sabatini(Broad Institute)
PI3K/AKT/mTOR signaling in cancerHippo pathway signaling and YAP/TAZBiologymTORC2P70-S6 Kinase 1Protein kinase BPI3K/AKT/mTOR pathwayCell biologymTORC1Signal transductionCancer research
MeSH terms
Forkhead Box Protein O3Glycogen Synthase Kinase 3 betaMechanistic Target of Rapamycin Complex 1Tuberous Sclerosis Complex 2 ProteinAnimalsCytoskeletonEmbryo, MammalianFetal ViabilityInsulinPhosphorylationProtein BindingProteinsTranscription FactorsSignal TransductionTrans-Activators
Funding
- Damon Runyon Cancer Research Foundation
- Massachusetts Institute of Technology
- National Institutes of Health
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
Citations
1,398
FWCI
24.57
field-weighted impact
References
45
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100%
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References
Mechanism of activation of protein kinase B by insulin and IGF-1.
The EMBO Journal · 1996 · 3,023 citations
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
Molecular Cell · 2006 · 2,633 citations
Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton
Current Biology · 2004 · 2,646 citations
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
Nature Cell Biology · 2004 · 2,097 citations
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Molecular Cell · 2002 · 1,883 citations
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