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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Molecular Cell · 2006 · Vol. 22(2) · pp. 159–168

Dos D. Sarbassov✉(Broad Institute)Siraj M. Ali(Broad Institute)Shomit Sengupta(Broad Institute)Joon-Ho Sheen(Broad Institute)Peggy P. Hsu(Broad Institute)Alex F. Bagley(Broad Institute)Andrew L. Markhard(Broad Institute)David M. Sabatini(Broad Institute)

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PI3K/AKT/mTOR signaling in cancer Protein Kinase Regulation and GTPase Signaling Metabolism, Diabetes, and CancermTORC2BiologyProtein kinase BPI3K/AKT/mTOR pathwayCell biologymTORC1Cancer researchPhosphorylationSignal transduction

MeSH terms

AnimalsAntibiotics, AntineoplasticCell LineCell SurvivalHeLa CellsHumansImmunohistochemistryMaleMice, NudeNeoplasm TransplantationPhosphorylationPrecipitin TestsRetroviridaeTime FactorsTranscription Factors

Funding

Howard Hughes Medical Institute
W. M. Keck Foundation
Rita Allen Foundation
Allen Foundation
National Institutes of Health

Citations

2,633

FWCI

51.85

field-weighted impact

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100%

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References

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The EMBO Journal · 1996 · 3,023 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Current Biology · 2004 · 2,646 citations

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

Cancer Research · 2006 · 2,544 citations

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Cell · 1999 · 6,532 citations

Growing roles for the mTOR pathway

Current Opinion in Cell Biology · 2005 · 1,547 citations

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Nature Cell Biology · 2004 · 2,097 citations

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