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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Cell · 1999 · Vol. 96(6) · pp. 857–868

Anne Brunet(Boston Children's Hospital)Azad Bonni(Boston Children's Hospital)Michael J. Zigmond(Boston Children's Hospital)Michael Z. Lin(Boston Children's Hospital)Peter Juo(Harvard University)Linda Hu(Boston Children's Hospital)Michael J. Anderson(Ludwig Cancer Research)Karen C. Arden(Ludwig Cancer Research)John Blenis(Harvard University)Michael E. Greenberg✉(Boston Children's Hospital)

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Nuclear Receptors and Signaling Signaling Pathways in Disease Protein Tyrosine PhosphatasesBiologyForkhead Transcription FactorsTranscription factorFOXA2PhosphorylationCell biologyProtein kinase BFOXO1Cancer researchGenetics

MeSH terms

Forkhead Box Protein O1Forkhead Box Protein O3Binding SitesCell Line, TransformedCell SurvivalCytoplasmDNA-Binding ProteinsHumansMembrane GlycoproteinsPhosphorylationProteinsProto-Oncogene ProteinsRecombinant Fusion ProteinsTranscription FactorsTyrosine 3-Monooxygenase

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Dynamic FoxO transcription factors