articleTop 1% cited
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
Nature Cell Biology · 2004 · Vol. 6(11) · pp. 1122–1128
Estela Jacinto(University of Basel)Robbie Loewith(University of Basel)Anja Schmidt(University College London)Shuo Lin(University of Basel)Markus A. Rüegg(University of Basel)Alan Hall(University College London)Michael N. Hall✉(University of Basel)
PI3K/AKT/mTOR signaling in cancerFungal and yeast genetics researchFungal Biology and ApplicationsmTORC2Cell biologyTOR signalingBiologymTORC1EffectorGTPaseActin cytoskeletonPI3K/AKT/mTOR pathwayActin
MeSH terms
ActinsAnimalsCell LineCytoskeletonHumansPhosphotransferases (Alcohol Group Acceptor)Cell Cycle ProteinsPhosphatidylinositol 3-KinasesSirolimusNIH 3T3 CellsMice
Funding
- National Institutes of Health
Citations
2,097
FWCI
20.42
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References
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
Oncogene · 2004 · 1,243 citations
Specificity and mechanism of action of some commonly used protein kinase inhibitors
Biochemical Journal · 2000 · 4,060 citations
Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton
Current Biology · 2004 · 2,646 citations
T-coffee: a novel method for fast and accurate multiple sequence alignment 1 1Edited by J. Thornton
Journal of Molecular Biology · 2000 · 7,021 citations
Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control
Molecular Cell · 2002 · 1,883 citations
Specificity and mechanism of action of some commonly used protein kinase inhibitors
Biochemical Journal · 2000 · 3,128 citations
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