article Open AccessTop 1% cited
Regulation of TORC1 by Rag GTPases in nutrient response
Nature Cell Biology · 2008 · Vol. 10(8) · pp. 935–945
Eunjung Kim✉Pankuri Goraksha-Hicks(University of Minnesota)Li Li(University of California, San Diego)Thomas P. Neufeld(University of Minnesota)Kun‐Liang Guan(University of California, San Diego)
PI3K/AKT/mTOR signaling in cancerCRISPR and Genetic EngineeringNeurobiology and Insect Physiology ResearchGTPaseAmino acidCell biologyBiologyDrosophila melanogasterGene knockdownGTP'AutophagyBiochemistryGene
MeSH terms
Amino AcidsAnimalsAutophagyCell LineDrosophila melanogasterFoodHumansProtein KinasesSignal TransductionPhosphatidylinositol 3-KinasesMonomeric GTP-Binding ProteinsDrosophila ProteinsRNA, Small InterferingCell SizeCell Proliferation
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References
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Nature Cell Biology · 2002 · 3,038 citations
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Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
Molecular Cell · 2002 · 1,548 citations
Upstream and downstream of mTOR
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