articleTop 1% cited
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Nature Cell Biology · 2002 · Vol. 4(9) · pp. 648–657
Ken Inoki✉(University of Michigan–Ann Arbor)Yong Li(University of Michigan–Ann Arbor)Tianquan Zhu(University of Michigan–Ann Arbor)Jun Wu(University of Michigan–Ann Arbor)Kun‐Liang Guan(University of Michigan–Ann Arbor)
Tuberous Sclerosis Complex ResearchPI3K/AKT/mTOR signaling in cancerPolyamine Metabolism and ApplicationsTSC2TSC1PI3K/AKT/mTOR pathwayProtein kinase BPhosphorylationP70-S6 Kinase 1RHEBCell biologymTORC1RPTOR
MeSH terms
Tuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 ProteinBinding SitesCarrier ProteinsCell LineHumansInsulinModels, BiologicalMutationPhosphoproteinsPhosphorylationProtein KinasesProteinsProto-Oncogene ProteinsRepressor Proteins
Funding
- National Institutes of Health
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