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Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Molecular Cell · 2010 · Vol. 39(2) · pp. 171–183
Katrin Düvel✉(Harvard University)Jessica L. Yecies(Harvard University)Suchithra Menon(Harvard University)Pichai Raman(Pathways Behavioral Services)Alex Lipovsky(Harvard University)Amanda L. Souza(Broad Institute)Ellen Triantafellow(Pathways Behavioral Services)Qicheng Ma(Pathways Behavioral Services)Regina Gorski(Pathways Behavioral Services)Stephen Cleaver(Pathways Behavioral Services)Matthew G. Vander Heiden(Koch Institute for Integrative Cancer Research At MIT)Jeffrey P. MacKeigan(Pathways Behavioral Services)Peter M. Finan(Pathways Behavioral Services)Clary B. Clish(Broad Institute)Leon O. Murphy(Pathways Behavioral Services)Brendan D. Manning(Harvard University)
Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and CancermTORC1BiologySterol regulatory element-binding proteinPentose phosphate pathwayTranscription factorPI3K/AKT/mTOR pathwayCell biologyMechanistic target of rapamycinP70-S6 Kinase 1Glycolysis
MeSH terms
Mechanistic Target of Rapamycin Complex 1AnimalsCell Line, TransformedGene Expression RegulationGlycolysisHumansLipidsNeoplasmsObesityPentose Phosphate PathwayProteinsTranscription FactorsTranscription, GeneticProtein BiosynthesisGenomics
Funding
- Tuberous Sclerosis Alliance
- National Institutes of Health
Citations
1,954
FWCI
31.64
field-weighted impact
References
52
Percentile
100%
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Citations per year
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References
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