review Open AccessTop 1% cited

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

Cancer Cell · 2012 · Vol. 21(3) · pp. 297–308

Patrick S. Ward(Memorial Sloan Kettering Cancer Center)Craig B. Thompson✉(Memorial Sloan Kettering Cancer Center)

Cancer, Hypoxia, and Metabolism Pancreatic function and diabetes Epigenetics and DNA MethylationWarburg effectReprogrammingBiologyCancerCell biologyCancer cellCancer researchGeneticsCell

MeSH terms

Cell DifferentiationHumansIsoenzymesMitochondriaModels, BiologicalNeoplasmsBiomarkers, TumorSignal TransductionProto-Oncogene Proteins c-mycAlternative SplicingEvolution, MolecularEpigenesis, GeneticCell Proliferation

Funding

University of Pennsylvania
National Institutes of Health
National Cancer Institute

Citations

3,226

FWCI

80.38

field-weighted impact

References

147

Percentile

100%

vs. same field & year

Citations per year

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References

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

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The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Cancer Cell · 2010 · 1,966 citations

Otto Warburg's contributions to current concepts of cancer metabolism

Nature reviews. Cancer · 2011 · 3,376 citations

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Cell Metabolism · 2006 · 2,210 citations

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Cell Metabolism · 2006 · 3,827 citations

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

Nature Medicine · 2011 · 2,230 citations

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

Cell Metabolism · 2012 · 1,086 citations

The Warburg effect: 80 years on

Biochemical Society Transactions · 2016 · 501 citations

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