article Open AccessTop 1% cited
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
Cell Metabolism · 2006 · Vol. 3(3) · pp. 187–197
Ioanna Papandreou(Stanford University)Rob A. Cairns(Stanford University)Lucrezia Fontana(Stanford University)Ai Lin Lim(Stanford University)Nicholas Denko✉(Stanford University)
Cancer, Hypoxia, and MetabolismMitochondrial Function and PathologyATP Synthase and ATPases ResearchGlycolysisCell biologyCitric acid cyclePyruvate dehydrogenase complexOxidative phosphorylationMitochondrionOxygen tensionOxygenPyruvate dehydrogenase kinaseBiology
MeSH terms
Pyruvate Dehydrogenase Acetyl-Transferring KinaseAdaptation, PhysiologicalAnimalsCells, CulturedHumansMitochondriaOxygen ConsumptionProtein KinasesDown-RegulationCell HypoxiaUp-RegulationApoptosisProtein Serine-Threonine KinasesMice, KnockoutComputational Biology
Funding
- National Cancer Institute
Citations
2,210
FWCI
36.01
field-weighted impact
References
53
Percentile
100%
vs. same field & year
Citations per year
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References
Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation
Biochemical Society Transactions · 2003 · 471 citations
Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α
Genes & Development · 1998 · 2,467 citations
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
JNCI Journal of the National Cancer Institute · 2001 · 2,637 citations
Up‐regulation of gene expression by hypoxia is mediated predominantly by hypoxia‐inducible factor 1 (HIF‐1)
The Journal of Pathology · 2005 · 449 citations
Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs
American Journal of Physiology-Endocrinology and Metabolism · 2003 · 505 citations
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
Cell Metabolism · 2005 · 1,498 citations
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