article Open AccessTop 1% cited
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
Cell Metabolism · 2005 · Vol. 1(6) · pp. 401–408
Robert D. Guzy(University of Chicago)Beatrice Hoyos(Memorial Sloan Kettering Cancer Center)Emmanuel Robin(University of Chicago)Hong Chen(University of Chicago)Liping Liu(University of Pennsylvania)Kyle D. Mansfield(University of Pennsylvania)M. Celeste Simon(Howard Hughes Medical Institute)Ulrich Hämmerling(Memorial Sloan Kettering Cancer Center)Paul T. Schumacker✉(University of Chicago)
Mitochondrial Function and PathologyCancer, Hypoxia, and MetabolismPhysiological and biochemical adaptationsReactive oxygen speciesMitochondrionCell biologyCytosolOxygenMitochondrial ROSHypoxia (environmental)BiophysicsChemistryBiology
MeSH terms
Endothelial PAS Domain-Containing Protein 1HypoxiaHumansHydrogen PeroxideMitochondriaOxygenTranscription FactorsElectron Transport Complex IIITrans-ActivatorsReactive Oxygen SpeciesCell Line, TumorBasic Helix-Loop-Helix Transcription FactorsBasic Helix-Loop-Helix ProteinsHypoxia-Inducible Factor 1, alpha Subunit
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1,498
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30
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References
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 in normoxia
The EMBO Journal · 2003 · 1,329 citations
Purification and Characterization of Hypoxia-inducible Factor 1
Journal of Biological Chemistry · 1995 · 2,061 citations
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation
Trends in Genetics · 1990 · 1,396 citations
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