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Topoisomerase I inhibitors: camptothecins and beyond

Nature reviews. Cancer · 2006 · Vol. 6(10) · pp. 789–802
Yves Pommier
Cancer therapeutics and mechanismsLung Cancer Research StudiesNeutropenia and Cancer InfectionsCamptothecinTopoisomeraseTopotecanIrinotecanChemistryContext (archaeology)DNA damageEnzymeDNARational design

MeSH terms

Antineoplastic AgentsCamptothecinDNA DamageDNA RepairDNA ReplicationEnzyme InhibitorsHumansNeoplasmsTopoisomerase I Inhibitors
Citations
2,190
FWCI
33.94
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152
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References
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
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Multidrug resistance in cancer: role of ATP–dependent transporters
Nature reviews. Cancer · 2002 · 5,468 citations
Targeting multidrug resistance in cancer
Nature Reviews Drug Discovery · 2006 · 3,630 citations
Induction of a Common Pathway of Apoptosis by Staurosporine
Experimental Cell Research · 1994 · 506 citations
Cellular roles of DNA topoisomerases: a molecular perspective
Nature Reviews Molecular Cell Biology · 2002 · 2,314 citations
DNA Topoisomerases: Structure, Function, and Mechanism
Annual Review of Biochemistry · 2001 · 2,695 citations
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