Scinovex
Life Sciences → Biochemistry, Genetics and Molecular Biology → Molecular Biology

Cancer therapeutics and mechanisms

This cluster of papers focuses on the structure, function, inhibition, and genetic variants of DNA topoisomerases, particularly their roles in chemotherapy, the mechanism of action of specific inhibitors such as irinotecan and quinolones, and their impact on genomic stability. The papers also explore the potential use of genetic variants in predicting drug toxicity and treatment outcomes.

54.3K works worldwide1.1M citations
TopoisomerasesDNAInhibitorsChemotherapyGenetic VariantsIrinotecanQuinolonesAnticancer DrugsEnzyme MechanismGenomic Stability

Journals publishing in this area

1Journal of Medicinal Chemistry cover
Journal of Medicinal Chemistry
ISSN 0022-26231,797 articles in this topic
366h-index
2Bioorganic & Medicinal Chemistry Letters cover
Bioorganic & Medicinal Chemistry Letters
ISSN 0960-894X1,668 articles in this topic
179h-index
3European Journal of Medicinal Chemistry cover
European Journal of Medicinal Chemistry
ISSN 0223-52341,500 articles in this topic
233h-index
4
Antimicrobial Agents and Chemotherapy
ISSN 0066-48041,375 articles in this topic
353h-index
5Bioorganic & Medicinal Chemistry cover
Bioorganic & Medicinal Chemistry
ISSN 0968-08961,122 articles in this topic
199h-index
6Biochemical Pharmacology cover
Biochemical Pharmacology
ISSN 0006-2952921 articles in this topic
290h-index
7European Journal of Cancer cover
European Journal of Cancer
ISSN 0959-8049880 articles in this topic
295h-index
8British Journal of Cancer cover
British Journal of Cancer
ISSN 0007-0920735 articles in this topic
344h-index
9Journal of Antimicrobial Chemotherapy cover
Journal of Antimicrobial Chemotherapy
ISSN 0305-7453538 articles in this topic
264h-index
10
Molecular Pharmacology
ISSN 0026-895X397 articles in this topic
273h-index