reviewTop 1% cited
Histone deacetylase inhibitors: molecular mechanisms of action
Oncogene · 2007 · Vol. 26(37) · pp. 5541–5552
Weisheng Xu✉(Memorial Sloan Kettering Cancer Center)Raphael B. Parmigiani(Memorial Sloan Kettering Cancer Center)P A Marks(Memorial Sloan Kettering Cancer Center)
Histone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsNuclear Receptors and SignalingBiologyVorinostatHistone deacetylaseProgrammed cell deathCell growthHistone deacetylase 5HistoneCell biologyCancer researchAcetylation
MeSH terms
Antineoplastic AgentsEnzyme InhibitorsHistone DeacetylasesHumansNeoplasmsSubstrate SpecificityGene ExpressionDrug Resistance, NeoplasmHistone Deacetylase Inhibitors
Funding
- Memorial Sloan-Kettering Cancer Center
- National Cancer Institute
Citations
1,533
FWCI
45.30
field-weighted impact
References
117
Percentile
100%
vs. same field & year
Citations per year
Cited by
Histone Deacetylase Inhibitors as Anticancer Drugs
International Journal of Molecular Sciences · 2017 · 1,159 citations
Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents
Molecules · 2015 · 673 citations
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas
Leukemia · 2008 · 439 citations
Histone deacetylase inhibitors: Potential in cancer therapy
Journal of Cellular Biochemistry · 2009 · 697 citations
HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention
Oncogene · 2007 · 1,023 citations
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
Nature Reviews Genetics · 2008 · 2,496 citations
Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi
Frontiers in Oncology · 2018 · 652 citations
HDAC expression and clinical prognosis in human malignancies
Cancer Letters · 2008 · 418 citations
References
Anticancer activities of histone deacetylase inhibitors
Nature Reviews Drug Discovery · 2006 · 2,905 citations
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
The EMBO Journal · 1998 · 2,368 citations
Acetylation and deacetylation of non-histone proteins
Gene · 2005 · 1,568 citations
Exploiting tumour hypoxia in cancer treatment
Nature reviews. Cancer · 2004 · 2,771 citations
Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey
Molecular Cell · 2006 · 1,476 citations
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
Nature reviews. Cancer · 2006 · 2,190 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.