Protein Degradation and Inhibitors

This cluster of papers focuses on the targeted degradation of specific proteins, particularly through the use of BET bromodomain inhibitors and PROTACs. The research explores the therapeutic potential of this approach, with a focus on histone recognition, small molecule inhibitors, and the role of epigenetic readers in transcriptional regulation. Additionally, it investigates the use of cereblon-dependent degradation and its implications for drug discovery.

Journals publishing in this area

1

Blood

ISSN 0006-49717,447 articles in this topic

636h-index

0.98Impact

197.5KArticles

5.6MCitations

2

Journal of Medicinal Chemistry

ISSN 0022-26231,109 articles in this topic

366h-index

5.89Impact

40.3KArticles

1.9MCitations

3

Leukemia

ISSN 0887-6924711 articles in this topic

256h-index

5.60Impact

11.6KArticles

622.2KCitations

4

European Journal of Medicinal Chemistry

ISSN 0223-5234640 articles in this topic

233h-index

4.95Impact

18.8KArticles

673.8KCitations

5

Molecular Cell

ISSN 1097-2765336 articles in this topic

528h-index

11.49Impact

10.5KArticles

1.7MCitations

6

Cancer Cell

Cancer Cell

ISSN 1535-6108180 articles in this topic

479h-index

26.09Impact

4.2KArticles

875.8KCitations

7

Nature Reviews Drug Discovery

ISSN 1474-1776156 articles in this topic

469h-index

11.63Impact

6.8KArticles

761.6KCitations

8

Nature reviews. Cancer

ISSN 1474-175X136 articles in this topic

592h-index

19.34Impact

4.7KArticles

1.1MCitations