reviewTop 1% cited
The rise of fragment-based drug discovery
Nature Chemistry · 2009 · Vol. 1(3) · pp. 187–192
Computational Drug Discovery MethodsCancer therapeutics and mechanismsProtein Structure and DynamicsDrug discoveryChemistryFragment (logic)Computational biologyAttritionLigand efficiencyBiochemical engineeringPharmaceutical industryVirtual screeningSmall molecule
MeSH terms
Binding SitesDrug Evaluation, PreclinicalMagnetic Resonance SpectroscopyCrystallography, X-RayProtein Kinase Inhibitorsbcl-X ProteinCyclin-Dependent Kinase 2Small Molecule Libraries
Citations
781
FWCI
35.50
field-weighted impact
References
48
Percentile
100%
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Citations per year
Cited by
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References
Physiochemical drug properties associated with in vivo toxicological outcomes
Bioorganic & Medicinal Chemistry Letters · 2008 · 954 citations
The influence of drug-like concepts on decision-making in medicinal chemistry
Nature Reviews Drug Discovery · 2007 · 2,269 citations
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Advanced Drug Delivery Reviews · 2001 · 17,620 citations
Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
Journal of Medicinal Chemistry · 2008 · 940 citations
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