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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
Cell Metabolism · 2007 · Vol. 6(6) · pp. 458–471
Cristina Mammucari(Veneto Institute of Molecular Medicine)Giulia Milan(Veneto Institute of Molecular Medicine)Vanina Romanello(Dulbecco Telethon Institute)Eva Masiero(Veneto Institute of Molecular Medicine)Rüdiger Rudolf(Veneto Institute of Molecular Medicine)Paola Del Piccolo(Veneto Institute of Molecular Medicine)Steven J. Burden(New York University)Raffaella Di Lisi(Veneto Institute of Molecular Medicine)Claudia Sandri(Dulbecco Telethon Institute)Jinghui Zhao(Harvard University)Alfred L. Goldberg(Harvard University)Stefano Schiaffino(Neuroscience Institute)Marco Sandri✉(Dulbecco Telethon Institute)
Autophagy in Disease and TherapyMuscle Physiology and DisordersSirtuins and Resveratrol in MedicineFOXO3AutophagyCell biologySkeletal muscleBiologyTranscription factorMuscle atrophyProtein kinase BTFEBIn vivo
MeSH terms
Forkhead Box Protein O3AnimalsAutophagyGene Expression RegulationLysosomesMembrane ProteinsMice, TransgenicMicrotubule-Associated ProteinsModels, BiologicalMuscular AtrophyProtein KinasesMuscle, SkeletalMitochondrial ProteinsUbiquitinRNA Interference
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References
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
Nature Cell Biology · 2001 · 2,692 citations
The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors
Molecular Cell · 2004 · 1,918 citations
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
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Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
Developmental Cell · 2006 · 1,398 citations
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy
Cell Death and Differentiation · 2006 · 603 citations
In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker
Molecular Biology of the Cell · 2003 · 2,285 citations
FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells
Cell Metabolism · 2007 · 1,458 citations
IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1
American Journal of Physiology-Endocrinology and Metabolism · 2004 · 599 citations
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