article Open AccessTop 1% cited
FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells
Cell Metabolism · 2007 · Vol. 6(6) · pp. 472–483
Jinghui Zhao(Harvard University)Jeffrey J. Brault(Harvard University)Andreas Schild(Harvard University)Peirang Cao(Harvard University)Marco Sandri(Dulbecco Telethon Institute)Stefano Schiaffino(University of Padua)Stewart H. Lecker(Harvard University)Alfred L. Goldberg✉(Harvard University)
Muscle Physiology and DisordersAutophagy in Disease and TherapyExercise and Physiological ResponsesFOXO3AutophagyMyogenesisMuscle atrophyCell biologyDenervationPI3K/AKT/mTOR pathwayUbiquitinProtein degradationAtrophy
MeSH terms
Forkhead Box Protein O3AnimalsAutophagyBase SequenceCell LineDNAGene Expression RegulationLysosomesModels, BiologicalMuscle ProteinsMuscular AtrophyMice, KnockoutMuscle Fibers, SkeletalPhosphatidylinositol 3-KinasesUbiquitin-Protein Ligases
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1,458
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References
The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors
Molecular Cell · 2004 · 1,918 citations
FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
Cell Metabolism · 2007 · 1,898 citations
Development by Self-Digestion
Developmental Cell · 2004 · 3,629 citations
In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker
Molecular Biology of the Cell · 2003 · 2,285 citations
A Unified Nomenclature for Yeast Autophagy-Related Genes
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IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1
American Journal of Physiology-Endocrinology and Metabolism · 2004 · 599 citations
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Cell · 1999 · 6,532 citations
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