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Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

Nature Reviews Molecular Cell Biology · 2008 · Vol. 9(5) · pp. 367–377

Adı́lson Guilherme✉(University of Massachusetts Chan Medical School)Joseph V. Virbasius(University of Massachusetts Chan Medical School)Vishwajeet Puri(University of Massachusetts Chan Medical School)Michael Czech(University of Massachusetts Chan Medical School)

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Adipose Tissue and Metabolism Lipid metabolism and biosynthesis Adipokines, Inflammation, and Metabolic DiseasesInsulin resistanceInternal medicineEndocrinologyAdipose tissueType 2 diabetesInsulinAdipocyteGlucose homeostasisGlucose uptakeObesity

MeSH terms

Adipose TissueAnimalsDiabetes Mellitus, Type 2HumansInflammationInsulinInsulin ResistanceLipolysisMitochondriaObesityTriglyceridesTumor Necrosis Factor-alphaSignal TransductionAdipocytesMuscle, Skeletal

Funding

National Institutes of Health

Citations

2,250

FWCI

53.56

field-weighted impact

References

147

Percentile

100%

vs. same field & year

Citations per year

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References

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Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

Diabetes · 1995 · 1,043 citations

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

Diabetologia · 2003 · 2,138 citations

Obesity-induced inflammatory changes in adipose tissue

Journal of Clinical Investigation · 2003 · 1,765 citations

Obesity is associated with macrophage accumulation in adipose tissue

Journal of Clinical Investigation · 2003 · 8,580 citations

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

Cell Metabolism · 2008 · 1,952 citations

Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis

Journal of Lipid Research · 2007 · 974 citations

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Diabetes · 1999 · 1,255 citations

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