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Obesity-induced inflammatory changes in adipose tissue
Journal of Clinical Investigation · 2003 · Vol. 112(12) · pp. 1785–1788
Kathryn E. Wellen✉(Harvard University)Gökhan S. Hotamışlıgil(Harvard University)
Abstract
Obesity is associated with a state of chronic, low-grade inflammation. Two manuscripts in this issue of the JCI (see the related articles beginning on pages 1796 and 1821) now report that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue. These studies prompt consideration of new models to include a major role for macrophages in the molecular changes that occur in adipose tissue in obesity.
Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and AdiposityAdipose tissueInflammationObesityAdipose tissue macrophagesInfiltration (HVAC)MacrophageMedicinePathologyEndocrinologyInternal medicine
MeSH terms
Adipose TissueAnimalsDiabetes Mellitus, Type 2Biological EvolutionHumansInflammationMacrophagesModels, BiologicalObesityTranscription, Genetic
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References
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Journal of Clinical Investigation · 2003 · 8,580 citations
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Journal of Clinical Investigation · 2003 · 5,825 citations
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Journal of Clinical Investigation · 2003 · 5,644 citations
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