articleTop 1% cited
An increase in the <i>Akkermansia</i> spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
Gut · 2013 · Vol. 63(5) · pp. 727–735
Na-Ri Shin(Kyung Hee University)June-Chul Lee(Sungkyunkwan University)Hae-Youn Lee(Samsung Medical Center)Min‐Soo Kim(Kyung Hee University)Tae Woong Whon(Kyung Hee University)Myung‐Shik Lee(Sungkyunkwan University)Jin‐Woo Bae✉(Kyung Hee University)
Abstract
Modulation of the gut microbiota (by an increase in the Akkermansia spp. population) may contribute to the antidiabetic effects of metformin, thereby providing a new mechanism for the therapeutic effect of metformin in patients with T2D. This suggests that pharmacological manipulation of the gut microbiota in favour of Akkermansia may be a potential treatment for T2D.
Gut microbiota and healthMetabolism, Diabetes, and CancerHelicobacter pylori-related gastroenterology studiesMetforminAkkermansiaAkkermansia muciniphilaGlucose homeostasisGut floraInternal medicineEndocrinologyType 2 diabetesPopulationAdipose tissue
MeSH terms
AnimalsBlood GlucoseDrug Administration ScheduleFlow CytometryHomeostasisHypoglycemic AgentsInflammationIntestinesMetforminMice, Inbred C57BLMice, ObeseBiomarkersIntra-Abdominal FatMiceDiet, High-Fat
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1,535
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