article Open AccessTop 1% cited
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Nature Medicine · 2005 · Vol. 11(2) · pp. 183–190
Dongsheng Cai✉Minsheng Yuan(Harvard University)Daniel Frantz(Vertex Pharmaceuticals (United States))Peter A. Meléndez(Hewlett-Packard (United States))Lone Hansen(Harvard University)Jongsoon Lee(Harvard University)Steven E. Shoelson(Harvard University)
Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismNF-κB Signaling PathwaysInsulin resistanceProinflammatory cytokineEndocrinologyInternal medicineIκB kinaseInflammationSystemic inflammationInsulinNF-κBBiology
MeSH terms
AnimalsAnti-Inflammatory Agents, Non-SteroidalDietary FatsFemaleHumansInsulinInsulin ResistanceMacrophagesMaleMice, Inbred C57BLMice, TransgenicObesitySalicylatesSignal TransductionInterleukin-6
Funding
- American Diabetes Association
- National Institutes of Health
Citations
2,216
FWCI
71.61
field-weighted impact
References
52
Percentile
100%
vs. same field & year
Citations per year
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References
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JAMA · 2001 · 4,400 citations
Inflammatory pathways and insulin action
International Journal of Obesity · 2003 · 716 citations
Fat Accumulation in the Liver Is Associated with Defects in Insulin Suppression of Glucose Production and Serum Free Fatty Acids Independent of Obesity in Normal Men
The Journal of Clinical Endocrinology & Metabolism · 2002 · 1,067 citations
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Journal of Clinical Investigation · 2003 · 5,825 citations
Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes
Diabetes · 2002 · 1,066 citations
Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001
JAMA · 2003 · 5,902 citations
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