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Rakesh K. Jain

Massachusetts General HospitalORCID https://orcid.org/0000-0001-7571-3548
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Top Publications

Angiogenesis in cancer and other diseases
Nature20008,970 citations
Photodynamic therapy for cancer
Nature reviews. Cancer20036,614 citations
Understanding the tumor immune microenvironment (TIME) for effective therapy
Nature Medicine20185,750 citations
A framework for advancing our understanding of cancer-associated fibroblasts
Nature reviews. Cancer20203,630 citations
Molecular regulation of vessel maturation
Nature Medicine20032,473 citationsFirst authorCorresponding
AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients
Cancer Cell20071,760 citationsCorresponding
Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness
American Journal Of Pathology20001,663 citations
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
Nature Reviews Drug Discovery20111,639 citations
Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia
Cancer Cell20141,503 citationsFirst authorCorresponding
Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology
Cancer Research20131,445 citations
Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors
Cancer Research20041,179 citations
Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors
American Journal Of Pathology2002970 citations
Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize
Journal of Cellular Biochemistry2006576 citationsCorresponding
Physiologically Based Pharmacokinetic Modeling: Principles and Applications
Journal of Pharmaceutical Sciences1983574 citationsCorresponding