article Open AccessTop 1% cited
Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness
American Journal Of Pathology · 2000 · Vol. 156(4) · pp. 1363–1380
Hiroya Hashizume✉(University of California, San Francisco)Peter Bałuk(University of California, San Francisco)Shunichi Morikawa(University of California, San Francisco)John W. McLean(University of California, San Francisco)Gavin Thurston(University of California, San Francisco)Sylvie Roberge(Harvard University)Rakesh K. Jain(Harvard University)Donald M. McDonald(University of California, San Francisco)
Angiogenesis and VEGF in CancerCell Adhesion Molecules ResearchCancer, Hypoxia, and MetabolismCD31TranscellularPathologyEndotheliumBiologyBlood vesselMicrovesselIntravasationEndothelial stem cellAngiogenesis
MeSH terms
AnimalsBlood VesselsCapillary PermeabilityEndothelium, VascularExtracellular SpaceFemaleMaleMicroscopy, ElectronMicroscopy, Electron, ScanningMicroscopy, FluorescenceNeoplasm TransplantationMammary Neoplasms, AnimalMice
Funding
- National Institutes of Health
- National Cancer Institute
Citations
1,663
FWCI
13.92
field-weighted impact
References
109
Percentile
99%
vs. same field & year
Citations per year
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References
STUDIES ON INFLAMMATION
The Journal of Cell Biology · 1961 · 1,530 citations
VEGFR-3 and Its Ligand VEGF-C Are Associated with Angiogenesis in Breast Cancer
American Journal Of Pathology · 1999 · 545 citations
Angiosarcoma of Soft Tissue
The American Journal of Surgical Pathology · 1998 · 511 citations
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.
The Journal of Experimental Medicine · 1995 · 2,500 citations
Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth
Cell · 1997 · 4,485 citations
Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry
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