review Open AccessTop 1% cited
PROTAC targeted protein degraders: the past is prologue
Nature Reviews Drug Discovery · 2022 · Vol. 21(3) · pp. 181–200
Miklós Békés(Arvinas (United States))David R. Langley(Arvinas (United States))Craig M. Crews✉(Yale University)
Protein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and AnalysisUbiquitinProteasomeProtein degradationComputational biologyDrug discoveryNeddylationMedicineBioinformaticsBiologyUbiquitin ligase
MeSH terms
HumansProteinsProteasome Endopeptidase ComplexProteolysis
Funding
- National Institutes of Health
Citations
2,833
FWCI
225.72
field-weighted impact
References
257
Percentile
100%
vs. same field & year
Citations per year
References
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The Ubiquitin Code
Annual Review of Biochemistry · 2012 · 3,574 citations
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
Angewandte Chemie International Edition · 2009 · 3,061 citations
Tau in physiology and pathology
Nature reviews. Neuroscience · 2015 · 2,133 citations
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