reviewTop 1% cited
PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives
European Journal of Medicinal Chemistry · 2016 · Vol. 109 · pp. 314–341
Vivek Asati(Guru Ghasidas Vishwavidyalaya)Debarshi Kar Mahapatra(Guru Ghasidas Vishwavidyalaya)Sanjay Kumar Bharti✉(Guru Ghasidas Vishwavidyalaya)
PI3K/AKT/mTOR signaling in cancerMelanoma and MAPK PathwaysSynthesis and biological activityPI3K/AKT/mTOR pathwayProtein kinase BMAPK/ERK pathwaySignal transductionKinaseCancer researchCarcinogenesisChemistryPhosphorylationCell biology
MeSH terms
AnimalsAntineoplastic AgentsEnzyme InhibitorsHumansNeoplasmsSignal Transductionras ProteinsPhosphatidylinositol 3-KinasesMAP Kinase Signaling Systemraf KinasesProto-Oncogene Proteins c-aktDrug DiscoveryTOR Serine-Threonine Kinases
Funding
- Indian Council of Medical Research
Citations
607
FWCI
23.32
field-weighted impact
References
158
Percentile
100%
vs. same field & year
Citations per year
References
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
Oncotarget · 2011 · 575 citations
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
Nature reviews. Cancer · 2009 · 2,438 citations
Phosphoinositide 3-kinases: A conserved family of signal transducers
Trends in Biochemical Sciences · 1997 · 945 citations
Radiotherapy and the Tumor Stroma: The Importance of Dose and Fractionation
Frontiers in Oncology · 2014 · 440 citations
Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ERα and ERβ Expressed in Chinese Hamster Ovary Cells
Molecular Endocrinology · 1999 · 1,033 citations
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Nature Cell Biology · 2002 · 3,038 citations
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
Oncogene · 2007 · 2,782 citations
Targeting PI3K/mTOR Signaling in Cancer
Frontiers in Oncology · 2014 · 1,030 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.