articleTop 1% cited
The TME Trial After a Median Follow-up of 6 Years
Annals of Surgery · 2007 · Vol. 246(5) · pp. 693–701
Koen Peeters✉(Leiden University Medical Center)Corrie A.M. Marijnen(The Netherlands Cancer Institute)Irıs D. Nagtegaal(Karolinska Institutet)Elma Meershoek‐Klein Kranenbarg✉Hein Putter(Leiden University Medical Center)Theo Wiggers(University Medical Center Groningen)H.J.T. Rutten(Catharina Ziekenhuis)Lars Påhlman✉Bengt Glimelius(Radboud University Medical Center)J.W.H. Leer(Leiden University Medical Center)Cornelis J.�H. van de Velde✉
Abstract
With increasing follow-up, there is a persisting overall effect of preoperative short-term radiotherapy on local control in patients with clinically resectable rectal cancer. However, there is no effect on overall survival. Since survival is mainly determined by distant metastases, efforts should be directed towards preventing systemic disease.
Colorectal Cancer Surgical TreatmentsColorectal and Anal CarcinomasColorectal Cancer Screening and DetectionMedicineTotal mesorectal excisionRadiation therapySurgeryColorectal cancerClinical endpointRegimenRandomized controlled trialCancerInternal medicine
MeSH terms
AdenocarcinomaAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedRectal NeoplasmsTime FactorsSurvival RateTreatment OutcomeRadiotherapy, AdjuvantNeoadjuvant Therapy
Citations
1,187
FWCI
32.27
field-weighted impact
References
40
Percentile
100%
vs. same field & year
Citations per year
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References
Circumferential Margin Involvement Is Still an Important Predictor of Local Recurrence in Rectal Carcinoma
The American Journal of Surgical Pathology · 2002 · 740 citations
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Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer
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