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Preoperative Versus Postoperative Chemoradiotherapy for Locally Advanced Rectal Cancer: Results of the German CAO/ARO/AIO-94 Randomized Phase III Trial After a Median Follow-Up of 11 Years

Journal of Clinical Oncology · 2012 · Vol. 30(16) · pp. 1926–1933

Rolf SauerTorsten Liersch(Klinikum Oldenburg)Susanne Merkel(Krankenhaus Dresden-Friedrichstadt)Rainer Fietkau(Goethe University Frankfurt)Werner Hohenberger(Friedrich-Alexander-Universität Erlangen-Nürnberg)Clemens F. Hess(Goethe University Frankfurt)Heinz Becker(Krankenhaus Dresden-Friedrichstadt)Hans-Rudolf Raab(Friedrich-Alexander-Universität Erlangen-Nürnberg)Marie-Therese Villanueva(Friedrich-Alexander-Universität Erlangen-Nürnberg)Helmut Witzigmann(Klinikum Oldenburg)Christian Wittekind(Goethe University Frankfurt)Tim Beißbarth(University Hospital Frankfurt)Claus Rödel✉(Krankenhaus Dresden-Friedrichstadt)

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Abstract

There is a persisting significant improvement of pre- versus postoperative CRT on local control; however, there was no effect on overall survival. Integrating more effective systemic treatment into the multimodal therapy has been adopted in the CAO/ARO/AIO-04 trial to possibly reduce distant metastases and improve survival.

Colorectal Cancer Surgical Treatments Colorectal and Anal Carcinomas Colorectal Cancer Treatments and StudiesMedicineColorectal cancerTotal mesorectal excisionCumulative incidenceSurgeryChemoradiotherapyIncidence (geometry)Clinical endpointRandomized controlled trialStage (stratigraphy)

MeSH terms

AdultAgedAntimetabolites, AntineoplasticCombined Modality TherapyFemaleFluorouracilFollow-Up StudiesGermanyHumansMaleMiddle AgedPostoperative PeriodRectal NeoplasmsTreatment OutcomeChemotherapy, Adjuvant