article Open AccessTop 10% cited
Interaction and uptake of exosomes by ovarian cancer cells
BMC Cancer · 2011 · Vol. 11(1) · pp. 108–108
Cristina Escrevente✉(Instituto de Biologia Experimental e Tecnológica)Sascha Keller(Heidelberg University)Peter Altevogt(German Cancer Research Center)Júlia Costa(Instituto de Biologia Experimental e Tecnológica)
Abstract
In conclusion, exosomes are internalized by ovarian tumor cells via various endocytic pathways and proteins from exosomes and cells are required for uptake. On the other hand, exosomes are enriched in specific glycoproteins that may constitute exosome markers. This work contributes to the knowledge about the properties and dynamics of exosomes in cancer.
Extracellular vesicles in diseaseRNA Interference and Gene DeliveryGalectins and Cancer BiologyMicrovesiclesEndocytosisEndocytic cycleCell biologyEndosomeBiochemistryChemistryBiologyCell
MeSH terms
Carcinoma, Ovarian EpithelialBiological TransportCells, CulturedEndocytosisFemaleFluoresceinsGlycoproteinsHumansLuminescent MeasurementsMicroscopy, FluorescenceNeoplasms, Glandular and EpithelialOvarian NeoplasmsProteinsSuccinimidesExosomes
Funding
- European Commission
- Fundação para a Ciência e a Tecnologia
Citations
661
FWCI
7.45
field-weighted impact
References
44
Percentile
98%
vs. same field & year
Citations per year
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References
Exosome: from internal vesicle of the multivesicular body to intercellular signaling device
Journal of Cell Science · 2000 · 1,068 citations
Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes).
Journal of Biological Chemistry · 1987 · 2,824 citations
Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
Nature Cell Biology · 2008 · 1,988 citations
Exosomes: endosomal-derived vesicles shipping extracellular messages
Current Opinion in Cell Biology · 2004 · 999 citations
Rab27a and Rab27b control different steps of the exosome secretion pathway
Nature Cell Biology · 2009 · 2,656 citations
Membrane vesicles as conveyors of immune responses
Nature reviews. Immunology · 2009 · 3,812 citations
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Nature Cell Biology · 2008 · 4,954 citations
Visualizing of the cellular uptake and intracellular trafficking of exosomes by live‐cell microscopy
Journal of Cellular Biochemistry · 2010 · 447 citations
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