article Open AccessTop 1% cited
Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection
PLoS Medicine · 2008 · Vol. 5(10) · pp. e203–e203
Lewis H. Kuller✉(University of Pittsburgh)Russell P. Tracy✉(University of Vermont)Waldo Belloso✉(Hospital Italiano de Buenos Aires)Stéphane De Wit✉(Centre Hospitalier Universitaire de Saint-Pierre)Fraser Drummond✉(National Centre for Clinical Research on Emerging Drugs)H. Clifford Lane✉(National Institute of Allergy and Infectious Diseases)Bruno Ledergerber✉(University Hospital of Zurich)Jens Lundgren✉(University of Copenhagen)Jacqueline Neuhaus✉(University of Minnesota)Daniel E. Nixon✉(Virginia Commonwealth University)Nicholas I. Paton✉(Medical Research Council)James D. Neaton✉(University of Minnesota)for the INSIGHT SMART Study Group
Abstract
IL-6 and D-dimer were strongly related to all-cause mortality. Interrupting ART may further increase the risk of death by raising IL-6 and D-dimer levels. Therapies that reduce the inflammatory response to HIV and decrease IL-6 and D-dimer levels may warrant investigation.
HIV-related health complications and treatmentsHIV/AIDS Research and InterventionsHIV Research and TreatmentMedicineInternal medicineBiomarkerOdds ratioConfidence intervalQuartileGastroenterologyC-reactive proteinFibrinogenD-dimer
MeSH terms
Serum Amyloid P-ComponentSerum Amyloid A ProteinBlood CoagulationC-Reactive ProteinCause of DeathFemaleFibrin Fibrinogen Degradation ProductsFollow-Up StudiesHumansInflammationMaleMulticenter Studies as TopicBiomarkersHIV InfectionsInterleukin-6
Funding
- Bristol-Myers Squibb
- Pfizer
- GlaxoSmithKline
- Gilead Sciences
- Wake Forest University
- Johns Hopkins University
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
Citations
1,595
FWCI
70.50
field-weighted impact
References
42
Percentile
100%
vs. same field & year
Citations per year
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References
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Associations of elevated Interleukin-6 and C-Reactive protein levels with mortality in the elderly
The American Journal of Medicine · 1999 · 1,479 citations
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Nature Medicine · 2006 · 3,514 citations
Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study
American Journal of Epidemiology · 1996 · 1,103 citations
Exploratory Data Analysis
Biometrics · 1977 · 12,886 citations
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