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Markers of Inflammation, Coagulation, and Renal Function Are Elevated in Adults with HIV Infection

The Journal of Infectious Diseases · 2010 · Vol. 201(12) · pp. 1788–1795

Jacqueline Neuhaus✉(University of Minnesota)David R. Jacobs(University of Minnesota)Jason V. Baker(University of Minnesota System)Alexandra Calmy(University of Geneva)Daniel Duprez(University of Minnesota System)Alberto La Rosa(Asociación Civil Impacta Salud y Educación)Lewis H. Kuller(University of Pittsburgh)Sarah Pett(UNSW Sydney)Matti Ristola(University of Helsinki)Michael J. Ross(Icahn School of Medicine at Mount Sinai)Michael G. Shlipak(University of California, San Francisco)Russell P. Tracy(University of Vermont)James D. Neaton(University of Minnesota System)

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Abstract

hsCRP, IL-6, D-dimer, and cystatin C levels are elevated in persons with HIV infection and remain so even after HIV RNA levels are suppressed with antiretroviral therapy. Additional research is needed on the pathophysiology of HIV-induced activation of inflammatory and coagulation pathways, to guide potential interventions.

HIV-related health complications and treatments HIV/AIDS Research and Interventions Pneumocystis jirovecii pneumonia detection and treatmentHuman immunodeficiency virus (HIV)ImmunologyInflammationCoagulationRenal functionMedicineInternal medicine

MeSH terms

AdultAgedBlood Coagulation DisordersC-Reactive ProteinFemaleFibrin Fibrinogen Degradation ProductsHumansInflammationKidney DiseasesMaleMiddle AgedBiomarkersHIV InfectionsInterleukin-6Anti-HIV Agents