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Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection
The Journal of Infectious Diseases · 2011 · Vol. 203(6) · pp. 780–790
Netanya G. Sandler✉(National Institutes of Health)Handan Wand(UNSW Sydney)Annelys Roque(National Institutes of Health)Matthew Law(UNSW Sydney)Martha Nason(National Institutes of Health)Daniel E. Nixon(Virginia Commonwealth University)Court Pedersen(University of Southern Denmark)Kiat Ruxrungtham(Chulalongkorn University)Sharon R. Lewin(Burnet Institute)Sean Emery(UNSW Sydney)James D. Neaton(University of Minnesota)Jason M. Brenchley(National Institutes of Health)Steven G. Deeks(San Francisco General Hospital)Irini Sereti(National Institutes of Health)Daniel C. Douek(National Institutes of Health)
Abstract
sCD14, a marker of monocyte response to LPS, is an independent predictor of mortality in HIV infection. Therapeutic attenuation of innate immune activation may improve survival in patients with HIV infection.
HIV-related health complications and treatmentsHIV Research and TreatmentImmune Cell Function and InteractionHuman immunodeficiency virus (HIV)MedicineImmunologyVirologyInternal medicine
MeSH terms
AdultCause of DeathHumansLipopolysaccharidesMaleMiddle AgedRNA, ViralBiomarkersCD4-Positive T-LymphocytesHIV InfectionsLogistic ModelsCase-Control StudiesLipopolysaccharide ReceptorsFatty Acid-Binding ProteinsYoung Adult
Funding
- National Center for Genetic Engineering and Biotechnology
- National Institutes of Health
Citations
1,096
FWCI
86.29
field-weighted impact
References
55
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100%
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References
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Nature Medicine · 2006 · 3,514 citations
Shorter Survival in Advanced Human Immunodeficiency Virus Type 1 Infection Is More Closely Associated with T Lymphocyte Activation than with Plasma Virus Burden or Virus Chemokine Coreceptor Usage
The Journal of Infectious Diseases · 1999 · 1,021 citations
T Cell Activation Is Associated with Lower CD4<sup>+</sup>T Cell Gains in Human Immunodeficiency Virus–Infected Patients with Sustained Viral Suppression during Antiretroviral Therapy
The Journal of Infectious Diseases · 2003 · 849 citations
CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract
The Journal of Experimental Medicine · 2004 · 1,809 citations
Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection
PLoS Medicine · 2008 · 1,595 citations
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