articleTop 1% cited
CYP2D6 and CYP2C19 genotype‐based dose recommendations for antidepressants: a first step towards subpopulation‐specific dosages
Acta Psychiatrica Scandinavica · 2001 · Vol. 104(3) · pp. 173–192
Julia Kirchheiner✉(Charité - Universitätsmedizin Berlin)Kim BrøsenMarja‐Liisa Dahl(Karolinska Institutet)L. F. GramSiegfried Kasper(University of Vienna)Ivar Roots(Charité - Universitätsmedizin Berlin)Folke Sjöqvist(Karolinska Institutet)Edoardo Spina(University of Messina)J. Brockmöller(University of Göttingen)
Abstract
We have provided preliminary average dose suggestions based on the phenotype or genotype. This is a first attempt to apply the new pharmacogenetics to suggest dose-regimens that take the differences in drug metabolic capacity into account.
Pharmacogenetics and Drug MetabolismTreatment of Major DepressionCancer Treatment and PharmacologyCYP2D6CYP2C19PharmacogeneticsPharmacologyDoseMedicineTricyclicDrugPharmacokineticsTherapeutic drug monitoring
MeSH terms
Antidepressive AgentsAryl Hydrocarbon HydroxylasesCytochrome P-450 Enzyme SystemDepressive DisorderDose-Response Relationship, DrugFemaleGenotypeHumansMixed Function OxygenasesMalePhenotypePolymorphism, GeneticDrug MonitoringCytochrome P-450 CYP2D6Cytochrome P-450 CYP2C19
Citations
422
FWCI
25.46
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References
192
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100%
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References
Incidence of Adverse Drug Reactions in Hospitalized Patients
JAMA · 1998 · 4,800 citations
Cytochrome P4502C9: an enzyme of major importance in human drug metabolism
British Journal of Clinical Pharmacology · 1998 · 844 citations
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