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Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient
PLoS Medicine · 2009 · Vol. 6(2) · pp. e1000029–e1000029
Ninette Amariglio(Sheba Medical Center)Abraham Hirshberg(Tel Aviv University)Bernd W. Scheithauer(Mayo Clinic)Yoram Cohen(Sheba Medical Center)Ron Loewenthal(Sheba Medical Center)Luba Trakhtenbrot(Sheba Medical Center)Nurit Paz(Sheba Medical Center)Maya Koren‐Michowitz(Sheba Medical Center)Dalia Waldman(Sheba Medical Center)Leonor Leider–TrejoAmos Toren(Sheba Medical Center)Shlomi Constantini(Tel Aviv University)Gideon Rechavi✉(Tel Aviv University)
Abstract
This is the first report of a human brain tumor complicating neural stem cell therapy. The findings here suggest that neuronal stem/progenitor cells may be involved in gliomagenesis and provide the first example of a donor-derived brain tumor. Further work is urgently needed to assess the safety of these therapies.
Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells ResearchMesenchymal stem cell researchNeural stem cellStem cellBrain tumorPathologyTransplantationCancer researchBiologyMedicineInternal medicineGenetics
MeSH terms
AdolescentAtaxia TelangiectasiaBrain NeoplasmsHumansMaleNeuronsStem CellsLiving DonorsStem Cell Transplantation
Funding
- Tel Aviv University
Citations
931
FWCI
42.79
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37
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References
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
Cancer Cell · 2006 · 2,310 citations
ATM and related protein kinases: safeguarding genome integrity
Nature reviews. Cancer · 2003 · 2,539 citations
Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro
Nature Biotechnology · 2000 · 2,701 citations
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