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Reported Methodologic Quality and Discrepancies between Large and Small Randomized Trials in Meta-Analyses
Annals of Internal Medicine · 2001 · Vol. 135(11) · pp. 982–989
Lise Lotte Kjaergard✉(Copenhagen University Hospital)John Villumsen(Copenhagen University Hospital)Christian Gluud(Copenhagen University Hospital)
Abstract
Inadequate generation of the allocation sequence, allocation concealment, and double blinding lead to exaggerated estimates of intervention benefit and may contribute to discrepancies between the results of large randomized trials and small randomized trials in meta-analyses.
Meta-analysis and systematic reviewsStatistical Methods in Clinical TrialsReliability and Agreement in MeasurementJadad scaleBlindingRandomized controlled trialMedicineOdds ratioRandomizationMeta-analysisClinical trialOddsInternal medicine
MeSH terms
Double-Blind MethodFollow-Up StudiesQuality ControlResearch DesignMeta-Analysis as TopicOdds RatioRandomized Controlled Trials as TopicSample Size
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2,318
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field-weighted impact
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References
Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials
JAMA · 1995 · 5,583 citations
Improving the quality of reporting of randomized controlled trials. The CONSORT statement
JAMA · 1996 · 3,349 citations
Bias in meta-analysis detected by a simple, graphical test
BMJ · 1997 · 55,187 citations
Empirical Evidence of Bias
JAMA · 1995 · 5,518 citations
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