article
Caco‐2 versus Caco‐2/HT29‐MTX Co‐cultured Cell Lines: Permeabilities Via Diffusion, Inside‐ and Outside‐Directed Carrier‐Mediated Transport
Journal of Pharmaceutical Sciences · 2000 · Vol. 89(1) · pp. 63–75
Constanze HilgendorfHildegard Spahn‐Langguth(Martin Luther University Halle-Wittenberg)C G Regårdh(AstraZeneca (Sweden))Elke Lipka(University of Michigan–Ann Arbor)Gordon L. Amidon(University of Michigan–Ann Arbor)Peter Langguth✉(Johannes Gutenberg University Mainz)
Drug Transport and Resistance MechanismsAdvanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsParacellular transportCaco-2ChemistryTranscellularPiroxicamBioavailabilityPermeability (electromagnetism)BiophysicsPharmacologyChromatography
MeSH terms
AntipyrineAtenololBiological Transport, ActiveCarrier ProteinsCell Membrane PermeabilityFurosemideHumansIntestinal AbsorptionIntestinal MucosaKetoprofenMannitolMetoprololMicroscopy, ElectronPiroxicamTerbutaline
Citations
464
FWCI
2.54
field-weighted impact
References
39
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90%
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References
Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa
Pharmaceutical Research · 1990 · 579 citations
Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability
Gastroenterology · 1989 · 2,193 citations
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
Biochemical and Biophysical Research Communications · 1991 · 1,852 citations
Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells
Journal of Pharmaceutical Sciences · 1990 · 833 citations
Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1
Advanced Drug Delivery Reviews · 2001 · 1,524 citations
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