review Open AccessTop 1% cited
Tumors as Organs: Complex Tissues that Interface with the Entire Organism
Developmental Cell · 2010 · Vol. 18(6) · pp. 884–901
Mikala Egeblad✉(Cold Spring Harbor Laboratory)Elizabeth S. Nakasone(Cold Spring Harbor Laboratory)Zena Werb(University of California, San Francisco)
Cancer Cells and MetastasisCancer, Hypoxia, and MetabolismSarcoma Diagnosis and TreatmentBiologyOrganismInterface (matter)Cell biologyComputational biologyGeneticsBiochemistry
MeSH terms
AnimalsCell Transformation, NeoplasticHumansImmune ToleranceNeoplasm MetastasisNeoplasmsNeovascularization, PathologicStromal CellsDrug Resistance, NeoplasmOrganogenesisCell Dedifferentiation
Funding
- National Institutes of Health
Citations
1,247
FWCI
28.92
field-weighted impact
References
195
Percentile
100%
vs. same field & year
Citations per year
Cited by
The extracellular matrix: A dynamic niche in cancer progression
The Journal of Cell Biology · 2012 · 2,974 citations
The Biology of YAP/TAZ: Hippo Signaling and Beyond
Physiological Reviews · 2014 · 1,805 citations
Role of EMT in Metastasis and Therapy Resistance
Journal of Clinical Medicine · 2016 · 489 citations
Dynamic interplay between the collagen scaffold and tumor evolution
Current Opinion in Cell Biology · 2010 · 878 citations
To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?
Journal of Controlled Release · 2016 · 1,197 citations
EPR: Evidence and fallacy
Journal of Controlled Release · 2014 · 799 citations
Understanding the tumor immune microenvironment (TIME) for effective therapy
Nature Medicine · 2018 · 5,750 citations
Microenvironmental regulation of tumor progression and metastasis
Nature Medicine · 2013 · 7,973 citations
References
Paradoxical roles of the immune system during cancer development
Nature reviews. Cancer · 2006 · 2,237 citations
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
Nature Cell Biology · 2007 · 1,544 citations
Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors
Cancer Research · 2004 · 1,179 citations
THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.
The Lancet · 1889 · 5,116 citations
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
Cancer Cell · 2009 · 3,276 citations
New functions for the matrix metalloproteinases in cancer progression
Nature reviews. Cancer · 2002 · 6,034 citations
Myeloid-derived suppressor cells as regulators of the immune system
Nature reviews. Immunology · 2009 · 6,584 citations
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Cell · 2010 · 4,974 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.