reviewTop 1% cited

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

Journal of Controlled Release · 2016 · Vol. 244(Pt A) · pp. 108–121

Nanoparticle-Based Drug Delivery Nanoplatforms for cancer theranostics RNA Interference and Gene DeliveryNanomedicineMedicineDrug deliveryNanotechnologyCancer therapyExploitElectron paramagnetic resonanceTumor microenvironmentPharmacologyCancer

MeSH terms

Tumor HypoxiaAntineoplastic AgentsExtracellular MatrixHumansNeoplasmsPermeabilityBiomarkers, TumorDrug Delivery SystemsNanostructuresNanomedicineTumor Microenvironment

Citations

1,197

FWCI

47.66

field-weighted impact

References

119

Percentile

100%

vs. same field & year

Citations per year

Cited by

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References

Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer

Trends in Pharmacological Sciences · 2009 · 1,305 citations

Strategies in the design of nanoparticles for therapeutic applications

Nature Reviews Drug Discovery · 2010 · 3,576 citations

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

Advanced Drug Delivery Reviews · 2010 · 3,472 citations

Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

Cancer Research · 2004 · 1,179 citations

Doxil® — The first FDA-approved nano-drug: Lessons learned

Journal of Controlled Release · 2012 · 4,472 citations

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

Journal of Controlled Release · 2000 · 6,447 citations

High interstitial fluid pressure — an obstacle in cancer therapy

Nature reviews. Cancer · 2004 · 2,134 citations

EPR: Evidence and fallacy

Journal of Controlled Release · 2014 · 799 citations

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