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Potent antimitotic and cell growth inhibitory properties of substituted chalcones

Bioorganic & Medicinal Chemistry Letters · 1998 · Vol. 8(9) · pp. 1051–1056

Sylvie Ducki(University of Manchester)Richard Forrest(University of Manchester)John A. Hadfield(Cancer Research UK Manchester Institute)Alex Guy Kendall(University of Manchester)Nicholas J. Lawrence✉(University of Manchester)Alan T. McGown(The Christie NHS Foundation Trust)David Rennison(Cancer Research UK Manchester Institute)

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Synthesis and biological activity Synthesis and Biological Evaluation Fungal Plant Pathogen ControlChemistryCytotoxicityChalconeStereochemistryK562 cellsCytotoxic T cellCell cultureIC50Chemical synthesisStructure–activity relationship

MeSH terms

Antineoplastic AgentsCell CycleCell DivisionCell SurvivalChalconeHumansModels, MolecularMolecular ConformationStructure-Activity RelationshipDrug DesignMolecular StructureCrystallography, X-RayK562 Cells

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366

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2.94

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Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents