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Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents

Bioorganic & Medicinal Chemistry Letters · 2005 · Vol. 15(12) · pp. 3177–3180
Bilal A. BhatK.L. DharS. C. PuriAjit Kumar SaxenaM. ShanmugavelGhulam N. Qazi
Synthesis and biological activityBioactive Compounds and Antitumor AgentsSynthesis of Organic CompoundsChemistryCytotoxic T cellCytotoxicityIn vitroStereochemistryCell cultureChalconeBiological activityCombinatorial chemistryChemical synthesis

MeSH terms

Antineoplastic AgentsChalconeDrug Screening Assays, AntitumorHumansNeoplasmsPyrazolesTumor Cells, CulturedInhibitory Concentration 50
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273
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6.32
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30
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97%
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References
Potent antimitotic and cell growth inhibitory properties of substituted chalcones
Bioorganic & Medicinal Chemistry Letters · 1998 · 366 citations
New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
JNCI Journal of the National Cancer Institute · 1990 · 9,711 citations
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