article Open AccessTop 1% cited
Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
Immunity · 1999 · Vol. 11(4) · pp. 443–451
Osamu Takeuchi(Japan Science and Technology Agency)Katsuaki Hoshino(Japan Science and Technology Agency)Taro Kawai(Japan Science and Technology Agency)Hideki Sanjo(Japan Science and Technology Agency)Haruhiko Takada(Tohoku University)Tomohiko Ogawa(Asahi University)Kiyoshi Takeda(Japan Science and Technology Agency)Shizuo Akira✉(Japan Science and Technology Agency)
Immune Response and InflammationPneumonia and Respiratory InfectionsAntimicrobial Peptides and ActivitiesLipoteichoic acidPeptidoglycanTLR2TLR4BiologyLipopolysaccharideMicrobiologyBacterial cell structureToll-like receptorIn vivo
MeSH terms
AnimalsAntigens, BacterialCell WallCorynebacterium diphtheriaeEscherichia coliFemaleGram-Negative BacteriaGram-Positive BacteriaLipid ALipopolysaccharidesMaleMembrane GlycoproteinsMice, Inbred C57BLNocardiaPeptidoglycan
Citations
3,351
FWCI
51.93
field-weighted impact
References
48
Percentile
100%
vs. same field & year
Citations per year
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References
Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product
The Journal of Immunology · 1999 · 3,357 citations
Unresponsiveness of MyD88-Deficient Mice to Endotoxin
Immunity · 1999 · 2,066 citations
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Molecular Cell · 1998 · 1,557 citations
Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction
Journal of Biological Chemistry · 1999 · 1,956 citations
Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
Immunity · 1998 · 2,015 citations
MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4
The Journal of Experimental Medicine · 1999 · 2,181 citations
Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (<i>Tlr4</i>)
The Journal of Experimental Medicine · 1999 · 1,535 citations
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Annual Review of Immunology · 1995 · 1,431 citations
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Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
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