reviewTop 1% cited

Oxidative Stress Hypothesis in Alzheimer's Disease

Free Radical Biology and Medicine · 1997 · Vol. 23(1) · pp. 134–147

William R. Markesbery✉(University of Kentucky)

Alzheimer's disease research and treatments Trace Elements in Health Cholinesterase and Neurodegenerative DiseasesOxidative stressLipid peroxidationChemistryFree-radical theory of agingHeme oxygenasePathogenesisSenile plaquesBiochemistry4-HydroxynonenalAlzheimer's disease

MeSH terms

Alzheimer DiseaseAntioxidantsDNA DamageFree RadicalsHumansNeuronsLipid PeroxidationAmyloid beta-PeptidesNeurofibrillary TanglesCell DeathOxidative Stress

Funding

National Institutes of Health

Citations

2,368

FWCI

36.33

field-weighted impact

References

218

Percentile

100%

vs. same field & year

Citations per year

Cited by

The Free Radical Theory of Aging Matures

Physiological Reviews · 1998 · 3,854 citations

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.

Diabetes · 1999 · 2,436 citations

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer’s disease brain contribute to neuronal death1

Neurobiology of Aging · 2002 · 713 citations

Oxidative Stress, Prooxidants, and Antioxidants: The Interplay

BioMed Research International · 2014 · 1,685 citations

Neurodegenerative diseases and oxidative stress

Biomedicine & Pharmacotherapy · 2003 · 1,020 citations

Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

Trends in Pharmacological Sciences · 2008 · 581 citations

Antioxidants and human diseases

Clinica Chimica Acta · 2014 · 511 citations

Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

Free Radical Biology and Medicine · 2002 · 990 citations

References

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress

Journal of the Neurological Sciences · 1996 · 537 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Neurology · 1993 · 3,794 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

Journal of Neurochemistry · 1997 · 775 citations

DISEASES OF THE NERVOUS SYSTEM

The American Journal of the Medical Sciences · 1918 · 1,287 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

Annals of Neurology · 1994 · 1,030 citations

Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca<sup>2+</sup> Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

Journal of Neurochemistry · 1995 · 616 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Science · 1993 · 9,373 citations

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

Journal of Neurochemistry · 1995 · 776 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.