articleTop 1% cited

Quantifying the chemical beauty of drugs

Nature Chemistry · 2012 · Vol. 4(2) · pp. 90–98

G. Richard Bickerton✉Gaia V. PaoliniJérémy Besnard(University of Dundee)Sorel Mureşan(AstraZeneca (Sweden))Andrew L. Hopkins(University of Dundee)

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Computational Drug Discovery MethodsDruggabilityChemistryMeasure (data warehouse)Quality (philosophy)Drug discoverySet (abstract data type)Key (lock)Property (philosophy)Biochemical engineeringComputer science

MeSH terms

Pharmaceutical PreparationsEmpirical Research

Funding

AstraZeneca

Citations

2,184

FWCI

52.65

field-weighted impact

References

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100%

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Citations per year

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References

How many drug targets are there?

Nature Reviews Drug Discovery · 2006 · 3,473 citations

Physiochemical drug properties associated with in vivo toxicological outcomes

Bioorganic & Medicinal Chemistry Letters · 2008 · 954 citations

The influence of drug-like concepts on decision-making in medicinal chemistry

Nature Reviews Drug Discovery · 2007 · 2,269 citations

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Journal of Medicinal Chemistry · 2009 · 4,214 citations

The druggable genome

Nature Reviews Drug Discovery · 2002 · 3,271 citations

Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Journal of Medicinal Chemistry · 2002 · 7,875 citations

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

Advanced Drug Delivery Reviews · 2001 · 17,620 citations

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

Journal of Medicinal Chemistry · 2008 · 940 citations

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