reviewTop 1% cited
Targeting the phosphoinositide 3-kinase pathway in cancer
Nature Reviews Drug Discovery · 2009 · Vol. 8(8) · pp. 627–644
Pixu Liu✉Hailing Cheng(Dana-Farber Cancer Institute)Thomas M. Roberts(Harvard University)Jean J. Zhao(Dana-Farber Cancer Institute)
PI3K/AKT/mTOR signaling in cancerChronic Lymphocytic Leukemia ResearchProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR pathwayPhosphoinositide 3-kinaseSignal transductionSignalling pathwaysCancerProtein kinase BKinaseCancer researchBiologyComputational biology
MeSH terms
Phosphoinositide-3 Kinase InhibitorsAnimalsAntineoplastic AgentsClinical Trials as TopicEnzyme InhibitorsHumansNeoplasmsProtein KinasesSignal TransductionDrug Delivery SystemsProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinases
Funding
- U.S. Department of Defense
Citations
2,742
FWCI
61.31
field-weighted impact
References
208
Percentile
100%
vs. same field & year
Citations per year
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References
AKT/PKB Signaling: Navigating Downstream
Cell · 2007 · 6,033 citations
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Nature Reviews Genetics · 2006 · 3,288 citations
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Nature Cell Biology · 2002 · 3,038 citations
A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer
Cancer Cell · 2007 · 1,609 citations
Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
PLoS Biology · 2009 · 1,072 citations
The PI3K–PDK1 connection: more than just a road to PKB
Biochemical Journal · 2000 · 1,590 citations
Molecular alterations of the <i>AKT</i>2 oncogene in ovarian and breast carcinomas
International Journal of Cancer · 1995 · 836 citations
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Nature Cell Biology · 2007 · 1,164 citations
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