reviewTop 1% cited
ERBB receptors and cancer: the complexity of targeted inhibitors
Nature reviews. Cancer · 2005 · Vol. 5(5) · pp. 341–354
Nancy E. Hynes✉(Friedrich Miescher Institute)Heidi A. Lane(Novartis Institutes for BioMedical Research)
HER2/EGFR in Cancer ResearchMonoclonal and Polyclonal Antibodies ResearchPI3K/AKT/mTOR signaling in cancerErbBReceptorReceptor tyrosine kinaseEpidermal growth factor receptorCancer researchTyrosine kinaseCancerBiologyGrowth factor receptor inhibitorGrowth factor receptor
MeSH terms
AnimalsAntibodies, MonoclonalAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsHumansNeoplasmsSignal TransductionDrug Delivery SystemsReceptor, ErbB-2Erb-b2 Receptor Tyrosine KinasesDrug Resistance, NeoplasmReceptor Protein-Tyrosine Kinases
Citations
3,292
FWCI
71.83
field-weighted impact
References
178
Percentile
100%
vs. same field & year
Citations per year
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References
The STATs of cancer — new molecular targets come of age
Nature reviews. Cancer · 2004 · 2,268 citations
Untangling the ErbB signalling network
Nature Reviews Molecular Cell Biology · 2001 · 6,890 citations
Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain
PLoS Medicine · 2005 · 3,519 citations
Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival
JNCI Journal of the National Cancer Institute · 1998 · 1,106 citations
EGF receptor ligands
Experimental Cell Research · 2003 · 767 citations
The Hallmarks of Cancer
Cell · 2000 · 28,385 citations
Regulation of tyrosine kinase cascades by G-protein-coupled receptors
Current Opinion in Cell Biology · 1999 · 690 citations
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
The EMBO Journal · 1997 · 1,569 citations
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