reviewTop 1% cited
ErbB receptors and signaling pathways in cancer
Current Opinion in Cell Biology · 2009 · Vol. 21(2) · pp. 177–184
Nancy E. Hynes✉(Friedrich Miescher Institute)Gwen MacDonald(Friedrich Miescher Institute)
HER2/EGFR in Cancer ResearchPI3K/AKT/mTOR signaling in cancerLung Cancer Treatments and MutationsBiologyErbBReceptor tyrosine kinaseEpidermal growth factor receptorCancer researchSignal transductionReceptorPI3K/AKT/mTOR pathwayGrowth factor receptorTyrosine kinase
MeSH terms
TrastuzumabAntibodies, MonoclonalAntineoplastic AgentsHumansMutationNeoplasmsSignal TransductionReceptor, ErbB-2Erb-b2 Receptor Tyrosine KinasesDrug Resistance, NeoplasmPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAntibodies, Monoclonal, HumanizedErbB Receptors
Funding
- Friedrich Miescher Institute for Biomedical Research
Citations
975
FWCI
29.68
field-weighted impact
References
70
Percentile
100%
vs. same field & year
Citations per year
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References
Untangling the ErbB signalling network
Nature Reviews Molecular Cell Biology · 2001 · 6,890 citations
ERBB receptors and cancer: the complexity of targeted inhibitors
Nature reviews. Cancer · 2005 · 3,292 citations
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers
International Journal of Cancer · 2005 · 661 citations
Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer
JNCI Journal of the National Cancer Institute · 2005 · 1,568 citations
The epidermal growth factor receptor family: Biology driving targeted therapeutics
Cellular and Molecular Life Sciences · 2008 · 756 citations
A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer
Cancer Cell · 2007 · 1,609 citations
EGF receptor ligands
Experimental Cell Research · 2003 · 767 citations
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
The EMBO Journal · 1997 · 1,569 citations
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