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Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival

JNCI Journal of the National Cancer Institute · 1998 · Vol. 90(11) · pp. 824–832

Jennifer R. Grandis✉(UPMC Hillman Cancer Center)Mona F. Melhem(University of Pittsburgh)William E. Gooding(UPMC Hillman Cancer Center)Roger Day(UPMC Hillman Cancer Center)Valerie A. Holst(University of Pittsburgh)Marilyn M. Wagener(University of Pittsburgh)Stephanie D. Drenning(University of Pittsburgh)David J. Tweardy(University of Pittsburgh)

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Abstract

Quantitation of EGFR and TGF-alpha protein levels in primary head and neck squamous cell carcinomas may be useful in identifying subgroups of patients at high risk of tumor recurrence and in guiding therapy.

Head and Neck Cancer Studies Salivary Gland Tumors Diagnosis and Treatment TGF-β signaling in diseasesMedicineHead and neck squamous-cell carcinomaEpidermal growth factor receptorOncologyImmunohistochemistryInternal medicineHead and neck cancerPrimary tumorCancerLymph node

MeSH terms

AdultAgedAntibodies, MonoclonalCarcinoma, Squamous CellFemaleHead and Neck NeoplasmsHumansImmunohistochemistryLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessNeoplasm ProteinsNeoplasm Recurrence, LocalRetrospective Studies

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Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy