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Dennis J. Selkoe

Harvard UniversityORCID https://orcid.org/0000-0001-8846-9767
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Top Publications

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
Science200213,715 citations
Alzheimer's Disease: Genes, Proteins, and Therapy
Physiological Reviews20016,050 citationsFirst authorCorresponding
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Nature Reviews Molecular Cell Biology20074,679 citations
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Nature Medicine20083,621 citations
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
The Lancet Neurology20143,256 citations
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
Nature Medicine19962,586 citations
Aβ Oligomers – a decade of discovery
Journal of Neurochemistry20071,905 citations
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
Nature Neuroscience20041,667 citations
Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway
Journal of Neuroscience20071,574 citations
Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
Behavioural Brain Research20081,006 citationsFirst authorCorresponding
Amyloid-β oligomers: their production, toxicity and therapeutic inhibition
Biochemical Society Transactions2002514 citations
Dennis J. Selkoe · Scinovex